The Buffalo Bills will face off against the Detroit Lions in a historic first regular-season game at Highmark Stadium during Thursday Night Football. The kickoff is scheduled for 8:15 p.m. ET and will be streamed live on Prime Video.
This matchup showcases two dynamic offenses, with a total points line set at an impressive 53.5 according to Kalshi. For insights on TNF odds, predictions, and top betting options, read on.
In their season openers, both teams combined for a staggering 67 points, while their defenses allowed a total of 61 points. Kalshi’s odds indicate that this Thursday night game is expected to be a high-scoring event. In their last encounter in 2024, the Bills edged out the Lions with a score of 48-42.
Best Bet for Lions vs. Bills: OVER 53.5 (-108)
The Bills scored 36 points in their opener against Houston, a team known for its strong defense. Now, Josh Allen and his teammates will take on a Detroit defense that struggled against New Orleans, where QB Tyler Shough threw for 410 yards and three touchdowns.
Detroit is missing three of its four starting secondary players, a vulnerability that Buffalo is likely to exploit. New wide receiver DJ Moore had an impressive debut for the Bills, catching five passes for 100 yards and a touchdown against the Texans, and he is expected to be heavily involved again on Thursday night.
While Buffalo demonstrated its ability to outscore one of the NFL's elite teams last week, its defense allowed 31 points to the Texans. The Lions have the offensive firepower to keep up with the Bills, featuring Jahmyr Gibbs, arguably the league's top running back, who rushed for 156 yards and two touchdowns on 29 carries against the Saints.
Quarterback Jared Goff also has a reliable target in Amon-Ra St. Brown, who recorded 10 receptions for 67 yards and two touchdowns against New Orleans. Fans can expect plenty of playmakers on the freshly re-sodded field of Highmark Stadium, which was revamped earlier this month.
Best Player Prop for Lions vs. Bills
Consider betting on Josh Allen to throw for over 250 passing yards (-108). Kalshi offers a range for Allen’s total passing yards, from 175 to 375. Given the performance Shough had against the Lions last week, it’s reasonable to expect Allen to surpass this mark comfortably. He threw for 334 yards against a solid Houston defense in the opener.
With Detroit’s secondary being particularly weak, betting on Allen to achieve 300+ passing yards is also a viable option, with +335 odds reflecting a 23% implied probability. The potential reward makes this bet worthwhile.
Anticipate a standout performance from Allen in his first official game at Highmark Stadium.